Tobramycin

Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

AntibioticsTobramycinLD 2mg/kg IV, then 1-1.5mg/kg IV QHDAdminister Post-HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
467952.527-60<50.22-0.3331.4-16650 (low flux)

References:

  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • Davis R, Koup J, Roon R, Opheim K, Smith A. Effect of oral activated charcoal on tobramycin clearance. Antimicrobial agents and chemotherapy 1988; 32(2), 274-5.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00684
  • Heintz B, Matzke G, Dager W. Antimicrobial dosing concepts and recommendations for critically ill adult patients receiving continuous renal replacement therapy or intermittent hemodialysis. Pharmacotherapy 2009; 29(5), 562-77.
  • Kamel Mohamed O, Wahba I, Watnick S et al. Administration of tobramycin in the beginning of the hemodialysis session: a novel intradialytic dosing regimen. Clinical journal of the American Society of Nephrology (CJASN) 2007; 2(4), 694-9.
  • Matzke G. Status of Hemodialysis of Drugs in 2002. Journal of Pharmacy Practice 2002; 15(5), 405-418.
  • Matzke G, Halstenson C, Keane W. Hemodialysis Elimination Rates and Clearance of Gentamicin and Tobramycin. Antimicrobial agents and chemotherapy 1984; 25(1), 128-32.
  • Péchère J, Dugal R. Pharmacokinetics of intravenously administered tobramycin in normal volunteers and in renal-impaired and hemodialyzed patients. The Journal of infectious diseases 1976; 134(Suppl), S118-24.