Gabapentin
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Analgesics (Misc.) | Gabapentin | 100-300mg PO HS | Administer Post-HD; if administer on HD, may need to supplement post HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 171 | 90 | 5-7 | 132 | <3 | 0.7 | 142 | 35 (low flux) |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00178
- Wong M, Eldon M, Keane W et al. Disposition of Gabapentin in Anuric Subjects on Hemodialysis. The Journal of Clinical Pharmacology. 1995;35(6):622-626.