Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Diabetes MedicationsPioglitazone15-45mg PO Q24HAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
356<13-7N/A>990.63N/ANo (N/A)


  • Abe M, Kikuchi F, Okada K, Matsumoto K. Plasma concentration of pioglitazone in patients with type 2 diabetes on hemodialysis. Therapeutic apheresis and dialysis. 2009;13(3):238-9.
  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB01132