Ibuprofen
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| NSAIDs | Ibuprofen | AVOID if possible; 300mg PO Q8H | Administer Anytime During HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 206 | 1 | 2-3.2 | Unchanged | 99 | 0.15-0.17 | 29.9-95 | 4-16.7 (low flux) |
References:
- Antal E, Ce W, Brown B, et al. The influence of hemodialysis on the pharmacokinetics of ibuprofen and its major metabolites. The Journal of Clinical Pharmacology. 1986;26(3):184-190.
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB01050
- Ochs H, Greenblatt D, Verburg-Ochs B. Ibuprofen kinetics in patients with renal insufficiency who are receiving maintenance hemodialysis. Arthritis and rheumatism. 1985;28(12):1430-1434.
- Senekjian H, Lee C, Kuo T, Au D, Krothapalli R. Absorption and disposition of ibuprofen in hemodialyzed uremic patients. European journal of rheumatology and inflammation. 1983;6(2):155-62.