Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

NSAIDsNaproxenAVOID if possible; 250mg PO Q12HAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
230<112-15Unchanged990.1N/ANo (low flux)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Weber S, Troutman W, Trujeque L. Effect of hemodialysis on plasma naproxen concentrations. American journal of hospital pharmacy. 1979;36(11):1567-9.