Morphine
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Opioids | Morphine | 50% of normal dose | Administer Post-HD; if administer on HD, may need to supplement post |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 285 | N/A | 2-4 | Unchanged (morphine); 41 (morphine-3-glucuronide) | 36 | 1-6 | 64-122 | 23-51 (high and low flux) |
References:
- Bastani B, Jamal J. Removal of morphine but not fentanyl during haemodialysis. Nephrology, dialysis, transplantation (official publication of the European Dialysis and Transplant Association - European Renal Association) 1997;12(12):2802-2804.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00295