Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

OpioidsMorphine50% of normal doseAdminister Post-HD; if administer on HD, may need to supplement post

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
285N/A 2-4Unchanged (morphine); 41 (morphine-3-glucuronide)361-664-12223-51 (high and low flux)


  • Bastani B, Jamal J. Removal of morphine but not fentanyl during haemodialysis. Nephrology, dialysis, transplantation (official publication of the European Dialysis and Transplant Association - European Renal Association) 1997;12(12):2802-2804.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: