Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

PsychotropicsDivalproexNormal dose based on indication; titrate according to target free valproic acid levelAdminister Post-HD, if feasible; For divided dosing in seizure indication, may require supplemental dose post-HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
310N/A9-16N/A80-900.16 (based on 70 kg)N/AN/A


  • Divalproex. In AHFS: Drug Information. Bethesda, MD: American Society of Health-System Pharmacists; 2012.