Divalproex
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Psychotropics | Divalproex | Normal dose based on indication; titrate according to target free valproic acid level | Administer Post-HD, if feasible; For divided dosing in seizure indication, may require supplemental dose post-HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 310 | N/A | 9-16 | N/A | 80-90 | 0.16 (based on 70 kg) | N/A | N/A |
References:
- Divalproex. In AHFS: Drug Information. Bethesda, MD: American Society of Health-System Pharmacists; 2012.