Cefuroxime Sodium
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Antibiotics | Cefuroxime Sodium | 750-1500mg IV Q24H | Administer Post-HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 424 | 90 | 1.2 | 17 | 35-50 | 0.13-1.8 | N/A | 18-25 (low flux) |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB01112
- Gower P, Kennedy M, Dash C. The effect of Renal Failure and Dialysis on the Pharmacokinetics of Cefuroxime. Proceedings of the Royal Society of Medicine 1977; 70(Suppl 9), 151-7.
- Kosmidis J, Stathakis C, Anyfantis A, Daikos G. Cefuroxime in renal insufficiency: therapeutic results in various infections and pharmacokinetics including the effects of dialysis. Proceedings of the Royal Society of Medicine 1977; 70(Suppl 9), 139-43.
- Van Dalen R, Vree T, Hafkenscheid J, Gimbrère J. Determination of plasma and renal clearance of cefuroxime and its pharmacokinetics in renal insufficiency. The Journal of antimicrobial chemotherapy 1979; 5(3), 281-92.